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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 2/28/2018
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Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment
Princeton Docket # 15-3159
Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 2/28/2018
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Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 3/15/2018
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Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): anitbiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Phosphohistidine Mimetics for the Development of Anti-Phosphohistidine Antibodies and Identification of Therapeutic Targets
Princeton Docket # 14-2972
Researchers in the Department of Chemistry at Princeton University have developed the first phosphohistidine (pHis)-specific antibody, which has enabled the selective detection and identification of pHis...
Published: 3/15/2018
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Inventor(s): Tom Muir, Rob Oslund, JunG-Min Kee
Keywords(s): antibody, biomarker/diagnostic, Biotechnology/Pharmaceuticals, Chemistry, drug discovery, drug target, life science research tools, posttranslational modification, protein engineering, protein phosphorylation, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry
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Voluntary Head
Restraint and Automated in vivo
Imaging System
Princeton Docket
#13-2837-1
Researchers at Department of Molecular Biology and the
Princeton Neuroscience Institute, have developed a rat operated kinematic
restraint clamp and automated in vivo imaging
system.
In neurosciences, measurement of neural activity in
animals by imaging...
Published: 3/15/2018
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Inventor(s): David Tank, Benjamin Scott, Carlos Brody
Keywords(s): CNS, drug discovery, Imaging, life science research tools
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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Princeton Docket # 12-2807
Researchers
in the Molecular Biology Department at Princeton University have discovered a
group of miRNAs as novel therapeutics for bone metastasis. Through
a series of in vitro and in vivo experiments, five distinctive miRNAs have been
identified as inhibitors of osteoclast differentiation. Further, systemic
treatment...
Published: 3/15/2018
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Inventor(s): Yibin Kang, Brian Ell
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, drug discovery, miRNA, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics
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Princeton Docket # 11-2672
Researchers at Princeton
University have developed a novel system for the rapid and specific induction of
individual genes, and upon modification, this system also allows for the rapid
and specific degradation of target proteins. Substantial induction/degradation of
target genes/proteins can be achieved within minutes...
Published: 3/15/2018
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Inventor(s): Sanford Silverman, Robert Mcisaac, David Botstein, Marcus Noyes
Keywords(s): drug discovery, life science research tools, platform technology
Category(s): Biotechnology/Pharmaceuticals
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Princeton
Docket # 11-2663
Researchers
at Princeton University created novel peptide derivatives of the antimicrobial
peptide Microcin J25 (MccJ25) with multiple amino acid substitutions and potent
activity against Gram-negative bacteria. The most potent MccJ25 variants
displayed up to a nearly 5-fold improvement in bacterial growth inhibition...
Published: 3/15/2018
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Inventor(s): A. James Link, Si Jia Pan
Keywords(s): anitbiotics, drug discovery, platform technology, therapeutic
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket #
11-2633
The ability to
selectively kill quiescent cells could be a powerful tool in medicine. In
particular, the ability to kill the quiescent tumor stem cells could be an
important addition to our chemotherapeutic repertoire. A better understanding of
the transition between quiescent and activated cellular states of fibroblasts...
Published: 3/15/2018
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Inventor(s): Hilary Coller
Keywords(s): cancer/oncology, drug discovery, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket #
10-2624/2706-1
At the present time
there are few, if any, ways to incorporate halogen atoms selectively into
complex compounds. Halogenated organic compounds play a central role in organic
chemistry, affording important components of a variety of biologically active
molecules as well as pharmacologically active reagents. Alkyl...
Published: 3/15/2018
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Inventor(s): John Groves, Wei Liu
Keywords(s): Biotechnology/Pharmaceuticals, drug discovery, platform technology, small molecule
Category(s): Chemistry, Biotechnology/Pharmaceuticals
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