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Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants
Princeton Docket # 15-3160
Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 2/28/2018
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Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment
Princeton Docket # 15-3159
Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 2/28/2018
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Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Princeton Docket # 15-3090Researchers in the Department of Molecular Biology at Princeton University and the School of Medicine at Dartmouth College have identified a novel strategy for inhibiting the pathogenesis of the human pathogen Pseudomonas aeruginosa by regulating its virulence factors upon surface contact instead of inhibiting its growth. ...
Published: 3/15/2018
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Inventor(s): Zemer Gitai, Albert Siryaporn, George O'toole, Sherry Kuchma
Keywords(s): anitbiotics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, drug discovery, infectious disease, life science research tools, small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics
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Use of Hyperthermal Atomic Beam for Low Temperature Diamond Growth
Princeton Docket #14-2959
High quality diamond films, currently grown only at high substrate temperatures, are desirable for their mechanical hardness, thermal conduction, electrical resistivity, durability and optical transparency. A low temperature process to produce such high quality...
Published: 3/15/2018
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Inventor(s): Samuel Cohen, Erik Gilson, Winston Chan
Keywords(s): aerospace, materials, small molecule, thin films
Category(s): Ceramics/Material Sciences
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Princeton Dockets # 08-2418, 12-2775 &
12-2776
Cholera, an infection caused by the bacterium Vibrio cholerae, is a life-threatening
disease. It is estimated that
cholera affects 3-5 million people worldwide, and causes
100,000-130,000 deaths a year as of 2010. Antibiotics such as doxycycline and
cotrimoxazole have been used to shorten the...
Published: 3/15/2018
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Inventor(s): Martin Semmelhack, Bonnie Bassler, Lark Perez, Megan Bolitho, Matthew Koch, WaI-Leung Ng
Keywords(s): anitbiotics, Biotechnology/Pharmaceuticals, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket #
11-2633
The ability to
selectively kill quiescent cells could be a powerful tool in medicine. In
particular, the ability to kill the quiescent tumor stem cells could be an
important addition to our chemotherapeutic repertoire. A better understanding of
the transition between quiescent and activated cellular states of fibroblasts...
Published: 3/15/2018
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Inventor(s): Hilary Coller
Keywords(s): cancer/oncology, drug discovery, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Princeton Docket #
10-2624/2706-1
At the present time
there are few, if any, ways to incorporate halogen atoms selectively into
complex compounds. Halogenated organic compounds play a central role in organic
chemistry, affording important components of a variety of biologically active
molecules as well as pharmacologically active reagents. Alkyl...
Published: 3/15/2018
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Inventor(s): John Groves, Wei Liu
Keywords(s): Biotechnology/Pharmaceuticals, drug discovery, platform technology, small molecule
Category(s): Chemistry, Biotechnology/Pharmaceuticals
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Princeton
University Invention # 09-2488
The
present invention relates to a series of novel analogues to compstatin. Based on
experimental SPR (Surface Plasmon Resonance) and IC50 binding data these new
analogues show greater binding affinity compared to native compstatin and are
therefore potentially more potent drug candidates for diseases related...
Published: 3/15/2018
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Inventor(s): Christodoulos Floudas (deceased) See Fotini P. Baba, Meghan Bellows Peterson, Dimitrios Morikis
Keywords(s): small molecule, therapeutic
Category(s): Biotechnology/Pharmaceuticals
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Princeton
Docket # 08-2467 & 08-2486
Researchers at
Princeton University, Department of Molecular Biology, have identified and
synthesized small molecule antagonists that could serve as broad spectrum lead
compounds for the disruption of quorum sensing in pathogenic Gram-negative
bacteria. In proof of principle experiments, potent antagonist...
Published: 3/15/2018
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Inventor(s): Bonnie Bassler, Lee Swem, Scott Ulrich, Colleen O'loughlin
Keywords(s): anitbiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals
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Quorum
Sensing is an essential form of intercellular communication used by many types
of common bacteria, and many pathogenic bacteria use quorum sensing to attack
and invade the human host. Quorum Sensing is used by bacteria to detect a
critical cell number, which is the cell population required for pathogenic
bacteria to release effective amounts...
Published: 3/15/2018
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Inventor(s): Bonnie Bassler, Michael Surette
Keywords(s): anitbiotics, drug target, small molecule
Category(s): Biotechnology/Pharmaceuticals
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