Search Results - john+groves

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A Direct Route to Prepare Isocyanates via C-H Activation for Drug Discovery Princeton Docket # 18-3374-1The first and only method for preparing high-valued aliphatic isocyanates via direct C-H activation has been developed by researchers at Princeton University. Organic isocyanates are versatile intermediates that provide access to a wide range of functionalities found in pharmaceuticals and agrochemicals. This method harnesses... Published: 2/5/2018   |   Inventor(s): John Groves, Xiongyi Huang, Thompson Zhuang Keywords(s):   Category(s): Biotechnology/Pharmaceuticals, Chemistry

A Green, Efficient, and Catalytic Method to Produce Chlorine Dioxide for the Purification and Treatment of Water Docket # 15-3063-1Researchers at Princeton University have developed a new catalytic method to produce chlorine dioxide quickly and efficiently from easily transportable chlorite salts. This method operates under mild conditions without the input of external energy or the use of harsh chemicals, circumventing the major concerns of large-scale production... Published: 3/15/2018   |   Inventor(s): John Groves, Roy Xiao Keywords(s): wastewater management Category(s): Chemistry, Civil/Environmental Engineering

A facile, no carrier added method for the preparation of [18F] Drugs and Building Blocks for PET Imaging Princeton docket, # 14-3015 A facile, no carrier added method for the preparation of [18F] Drugs and Building Blocks for PET Imaging Princeton docket, # 14-3015 Princeton researchers in the department of chemistry together with colleagues at the Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School have developed the first... Published: 3/15/2018   |   Inventor(s): John Groves, Xiongyi Huang, Wei Liu, Jacob Hooker Keywords(s):   Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

An Efficient, Green Process for Cyanide Decontamination in Water An Efficient, Green Process for Cyanide Decontamination in Water Princeton Docket # 14-2955 This innovation is an improvement to a previously patent pending process for the catalytic generation of chlorine dioxide, Princeton docket # 11-2630/2714, US Patent Publication 2013-0209573, “An Efficient, Catalytic and Scalable Method to Produce Chlorine... Published: 3/15/2018   |   Inventor(s): John Groves, Thomas Umile, Christina Chang Keywords(s): catalyst, Chemistry, energy, green tech, wastewater management, water Category(s): Chemistry

Selective Fluorination of Drug Molecules for Higher Potency, Improved Pharmacology and Lower Metabolic Burden Princeton Docket # 12-2797/2758-1Chemists in the laboratory of Professor John T Groves, Princeton University have discovered a powerful, simple and potentially disruptive technology for drug diversification through direct fluorination (3D-F). Fluorine is a highly desirable drug component because replacement of hydrogen with fluorine usually results... Published: 3/15/2018   |   Inventor(s): John Groves, Wei Liu, Xiongyi Huang Keywords(s):   Category(s): Biotechnology/Pharmaceuticals, Chemistry

A Green, Efficient, and Catalytic Method to Produce Chlorine Dioxide for the Purification and Treatment of Water Princeton Docket # 11-2630-1 Researchers at Princeton University have developed a new catalytic method to produce chlorine dioxide quickly and efficiently from easily transportable chlorite salts. This method operates under mild conditions and without the input of external energy or use of harsh chemicals, circumventing the major concerns of... Published: 3/15/2018   |   Inventor(s): John Groves, Thomas Umile Keywords(s):   Category(s): Chemistry

Halogenation of Complex Compounds to enable Drug Diversification and Novel Small Molecules Princeton Docket # 10-2624/2706-1 At the present time there are few, if any, ways to incorporate halogen atoms selectively into complex compounds. Halogenated organic compounds play a central role in organic chemistry, affording important components of a variety of biologically active molecules as well as pharmacologically active reagents. Alkyl... Published: 3/15/2018   |   Inventor(s): John Groves, Wei Liu Keywords(s): Biotechnology/Pharmaceuticals, drug discovery, platform technology, small molecule Category(s): Chemistry, Biotechnology/Pharmaceuticals

A Novel Method of Interfering with Iron Uptake by Mycobacterium Tuberculosis and Related Organisms Princeton Invention # 04-2103 Researchers in the Chemistry Department at Princeton University have discovered a novel pathway which may allow for a new pharmacological approach to the control of tuberculosis. The rational discovery of drugs requires prior knowledge of metabolic pathways. Usually this involves identifying the function... Published: 3/15/2018   |   Inventor(s): John Groves Keywords(s): Chemistry Category(s): Biotechnology/Pharmaceuticals

Novel Metalloporphyrins and Related Metal Complexes for the Treatment of Oxidative Stress and Diseases with Oxidative Components Princeton Invention # 99-1608 Researchers in the Chemistry Department at Princeton University have developed novel metalloporphyrins that offer new potential pharmaceuticals for the treatment of diseases such as diabetes, ischemia-reperfusion injury, stroke, inflammation, neurodegeneration, and sepsis in which active oxygen (ROS)... Published: 3/15/2018   |   Inventor(s): John Groves, Suzanne Moeller Keywords(s):   Category(s): Biotechnology/Pharmaceuticals