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A Direct Route to Prepare Isocyanates via C-H Activation for Drug Discovery

Princeton Docket # 18-3374-1The first and only method for preparing high-valued aliphatic isocyanates via direct C-H activation has been developed by researchers at Princeton University. Organic isocyanates are versatile intermediates that provide access to a wide range of functionalities found in pharmaceuticals and agrochemicals. This method harnesses...
Published: 2/5/2018   |   Inventor(s): John Groves, Xiongyi Huang, Thompson Zhuang
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals, Chemistry

Calibration Procedures for Rotating Lorentz-Force Flowmeters: Non-Contact Flow Measurement for Electrically Conductive Fluids

Princeton Docket # 17-3301Measuring the flowrate of extremely high-temperature or chemically aggressive fluids is a challenge faced by a variety of different industrial processes (e.g. metal casting, nuclear power, concentrated solar power, chemical production, etc.). Rotating Lorentz-force flowmeters (RLFFs) are non-contact devices that can operate...
Published: 2/2/2018   |   Inventor(s): Michael Hvasta
Keywords(s):  
Category(s): Chemistry, Ceramics/Material Sciences, Mechanical, Opto-Electronics/ Electrical Engineering

Knockout Sudoku: A unique method for creation of whole genome knockout collections

Princeton Docket # 16-3258-1Researchers at Princeton in the Department of chemistry have invented a new method that significantly lowers the cost, time and complexity for construction of whole genome knockout collection. Whole genome knockout collections could accelerate gene and drug target discoveries by providing new insights into antibiotic resistance,...
Published: 3/1/2022   |   Inventor(s): Buz Barstow, Michael Baym, Lev Shaket, Isao Anzai, Oluwakemi Adesina
Keywords(s):  
Category(s): Chemistry

New Tri(1-adamantyl)phophine Ligand for Improved Transition Metal Catalysis

Princeton Docket # 16-3202-1Researchers in the Department of Chemistry at Princeton University have developed a new ligand for cross-coupling reactions to use in conjunction with transition metal catalysts. Modern palladium catalysts for cross-coupling chemistry rely predominantly on phosphine or N-heterocyclic carbene ligands to enhance their reactivity...
Published: 1/29/2018   |   Inventor(s): Brad Carrow, Liye Chen
Keywords(s):  
Category(s): Chemistry

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Repair Mutants Princeton Docket # 15-3160 Researchers in the Department of Molecular Biology at Princeton University have identified drug resistance mutations in key pathways in chemoresistance using the mutator phenotype of mismatch repair defective Saccharomyces cerevisiae cells and...
Published: 2/28/2018   |   Inventor(s): Alison Gammie, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, life science research tools, model organism, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Synthetic Lethal Targeting of Mismatch Repair Defective Cells

Synthetic Lethal Targeting of Mismatch Repair Defective Cells for Cancer Treatment Princeton Docket # 15-3159 Researchers in the Department of Molecular Biology at Princeton University have developed a yeast-based high throughput chemical synthetic lethality screen to identify clinically relevant small molecules. Its application has led to the discovery...
Published: 2/28/2018   |   Inventor(s): Alison Gammie, Hahn Kim, Irene Ojini
Keywords(s): biologics, biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, Chemistry, drug discovery, drug target, new molecules, platform technology, research tool, small molecule, yeast
Category(s): Biotechnology/Pharmaceuticals, Chemistry, Medical Devices/Diagnostics

Behaviorally-motivated Innovation for Hand Hygiene and Infection Control

Princeton Docket # 15-3154-1Researchers at Princeton University, departments of psychology and public affairs, along with researchers at Sunnybrook Health Sciences Centre, Toronto, have co-developed a behaviorally motivated innovation for infection control and hand hygiene.Clinician failure to wash hands before interacting with patients is a well-recognized...
Published: 2/28/2018   |   Inventor(s): Eldar Shafir, Donald Redelmeir
Keywords(s): anti-infectives
Category(s): Chemistry, Medical Devices/Diagnostics

Selective C-H Fluorination of Organic Compounds Using an Earth-abundant Visible Light Photocatalyst

Princeton Docket # 15-3146-1Researchers in the Department of Chemistry at Princeton University have developed a new C-H fluorination method that uses uranium as a visible light photocatalyst. The fluorination of unactivated Csp3–H bonds remains a desirable, challenging transformation for pharmaceutical, agricultural, and materials scientists....
Published: 3/8/2018   |   Inventor(s): Erik Sorensen, Julian West
Keywords(s):  
Category(s): Chemistry

Fluorinated Electrolytes for Magnesium-Ion Batteries

Princeton Docket # 15-3142/3143/16-3237Researchers in the Department of Chemistry and Department of Mechanical and Aerospace Engineering at Princeton University have developed electrolyte formulations for magnesium-ion (Mg-ion) batteries that exhibit high conductivity, a large voltage window, and reversible magnesium electrodeposition. This technology...
Published: 1/29/2018   |   Inventor(s): Jake Herb, Craig Arnold, Carl NisT-Lund
Keywords(s):  
Category(s): Chemistry, Ceramics/Material Sciences

Process for Acceptorless Dehydrogenation of Alkanes Through Dual Catalysis

Dual Base Metal Catalysis for Alkene and Hydrogen Production via Acceptorless and Selective Dehydrogenation of Alkanes Princeton Docket # 15-3117 Researchers in the Department of Chemistry at Princeton University have developed a new catalyst combination, comprising of a tungsten-based polyoxometalate and cobaloxime, in order to dehydrogenate alkanes...
Published: 3/15/2018   |   Inventor(s): Erik Sorensen, Julian West
Keywords(s): catalyst, Chemistry, organic synthesis, petrochemical, research tool
Category(s): Chemistry
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