Description:
This technology uses
novel glycosylated steroid derivatives to facilitate the transport of molecules
of a second compound across biological membranes. The facilitation is achieved
by combining the derivatives with the molecules of interest, either as a
conjugate comprising the derivative covalently linked directly or indirectly
with the molecule of interest or as an admixture comprising the two main
components. In this manner, the molecule of interest, especially those of a
therapeutic si gnificance, can better exhibit its activity, whether of a
biological, physical or chemical nature. The technology also encompasses novel
methods for the efficient synthesis of these derivatives, including their
combinations with representative molecules of interest.
The glycosylated
steroid derivatives of the present technology can interact with a wide variety
of membranes, including biological phospholipid membranes, thereby possessing
the potential to enhance the penetration of
therapeutically-significant-compounds through such membranes. Princeton is
currently seeking industrial collaborators to commercialize this
technology.
Patent
protection has been granted.
For more information please
contact:
William H. Gowen
Office of Patents and
Licensing
Princeton University
4
New South Building
Princeton, NJ 08544-0036
(609) 258-6762
(609) 258-1159 fax
wgowen@princeton.edu